In his research, Gert Salentijn investigated several approaches to decrease the dependence of chemical analysis on stationary laboratory facilities to make it more accessible, or as it is popularly phrased: “to bring the lab to the sample, instead of the sample to the lab”. This type of approach has been receiving a lot of attention recently, driven by a strong need in (low-resource) point-of-care settings for speed, flexibility and cost-effectiveness in disease diagnosis.
This project was financed by the Netherlands Organization for Scientific Research (NWO), and aimed to develop disposable sample interfaces for on-site analysis with a portable mass-spectrometric instrument. At the core of the research lies a simple, yet elegant material that already has a long history in science, namely paper. By approaching this material in a number of different ways, amongst which the integration into 3D-printed devices, it has proven possible to leverage paper-based analysis. The tools and techniques that were developed in the research encompass a range of new functionalities that can be applied to making smarter and better tests, while ensuring affordability. The dissertation can be found here.